Use of electronic healthcare records in large-scale simple randomized trials at the point of care for the documentation of value-based medicine
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Publication date
2014-06
Authors
van Staa, T P
Klungel, Olaf H.
Smeeth, L.
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Document Type
Article
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Abstract
A solid foundation of evidence of the effects of an intervention is a prerequisite of evidence-based medicine. The best source of such evidence is considered to be randomized trials, which are able to avoid confounding. However, they may not always estimate effectiveness in clinical practice. Databases that collate anonymized electronic health records (EHRs) from different clinical centres have been widely used for many years in observational studies. Randomized point-of-care trials have been initiated recently to recruit and follow patients using the data from EHR databases. In this review, we describe how EHR databases can be used for conducting large-scale simple trials and discuss the advantages and disadvantages of their use.
Keywords
Clinical trials, Epidemiology, ISRCTN33113202, article, clinical practice, data base, electronic medical record, evidence based medicine, general practice, general practitioner, health care, health care system, hospital, hospital admission, human, medical documentation, medical specialist, priority journal, randomized controlled trial (topic), Internal Medicine, SDG 3 - Good Health and Well-being
Citation
Van Staa, T-P, Klungel, O & Smeeth, L 2014, 'Use of electronic healthcare records in large-scale simple randomized trials at the point of care for the documentation of value-based medicine', Journal of Internal Medicine, vol. 275, no. 6, pp. 562-569. https://doi.org/10.1111/joim.12211