Bacterial Infection Disrupts Clock Gene Expression to Attenuate Immune Responses
Publication date
2020-05-04
Authors
de Leone, María José
Hernando, C. Esteban
Romanowski, Andrés
Careno, Daniel A.
Soverna, Ana Faigón
Sun, Hequan
Bologna, Nicolás G.
Vázquez, Martín
Schneeberger, Korbinian
Yanovsky, Marcelo J.
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Article
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Abstract
Little is known regarding the mechanisms involved in the clock-immunity crosstalk. de Leone et al. report that the defense mutant eds4 carries a mutation in NUCLEOPORIN205 which affects its circadian function, and that leads to an attenuation of the transcriptional reprogramming in core clock genes that take place soon after a bacterial infection.
Keywords
eds4, circadian clock, Enhanced Disease Susceptibility 4, LNK, NIGHT LIGHT-INDUCIBLE AND CLOCK-REGULATED, NPC, Nuclear Pore Complex, plant-pathogen interactions, General Biochemistry,Genetics and Molecular Biology, General Agricultural and Biological Sciences
Citation
de Leone, M J, Hernando, C E, Romanowski, A, Careno, D A, Soverna, A F, Sun, H, Bologna, N G, Vázquez, M, Schneeberger, K & Yanovsky, M J 2020, 'Bacterial Infection Disrupts Clock Gene Expression to Attenuate Immune Responses', Current Biology, vol. 30, no. 9, pp. 1740-1747.e6. https://doi.org/10.1016/j.cub.2020.02.058