Genetic association signal near NTN4 in Tourette syndrome
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Publication date
2014-08
Authors
Paschou, Peristera
Yu, Dongmei
Gerber, Gloria
Evans, Patrick
Tsetsos, Fotis
Davis, Lea K
Karagiannidis, Iordanis
Chaponis, Jonathan
Gamazon, Eric
Mueller-Vahl, Kirsten
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Article
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Abstract
Tourette syndrome (TS) is a neurodevelopmental disorder with a complex genetic etiology. Through an international collaboration, we genotyped 42 single nucleotide polymorphisms (p < 10(-3) ) from the recent TS genomewide association study (GWAS) in 609 independent cases and 610 ancestry-matched controls. Only rs2060546 on chromosome 12q22 (p = 3.3 × 10(-4) ) remained significant after Bonferroni correction. Meta-analysis with the original GWAS yielded the strongest association to date (p = 5.8 × 10(-7) ). Although its functional significance is unclear, rs2060546 lies closest to NTN4, an axon guidance molecule expressed in developing striatum. Risk score analysis significantly predicted case-control status (p = 0.042), suggesting that many of these variants are true TS risk alleles.
Keywords
Adult, Case-Control Studies, Genome-Wide Association Study, Humans, Nerve Growth Factors, Polymorphism, Single Nucleotide, Tourette Syndrome
Citation
Paschou, P, Yu, D, Gerber, G, Evans, P, Tsetsos, F, Davis, L K, Karagiannidis, I, Chaponis, J, Gamazon, E, Mueller-Vahl, K, Stuhrmann, M, Schloegelhofer, M, Stamenkovic, M, Hebebrand, J, Noethen, M, Nagy, P, Barta, C, Tarnok, Z, Rizzo, R, Depienne, C, Worbe, Y, Hartmann, A, Cath, D C, Budman, C L, Sandor, P, Barr, C, Wolanczyk, T, Singer, H, Chou, I-C, Grados, M, Posthuma, D, Rouleau, G A, Aschauer, H, Freimer, N B, Pauls, D L, Cox, N J, Mathews, C A & Scharf, J M 2014, 'Genetic association signal near NTN4 in Tourette syndrome', Annals of Neurology, vol. 76, no. 2, pp. 310-5. https://doi.org/10.1002/ana.24215