Possible intermediates in the biosynthesis of proteins. I. Evidence for the presence of nucleotide-bound carboxyl-activated peptides in baker's yeast

Abstract

1. 1. In this paper evidence is presented for the occurrence of dialysable nucleotide-bound carboxyl-activated peptide compounds in extracts of ether-CO2-frozen fresh pressed baker's yeast.

2. 2. Furthermore, some data are given indicating the presence of carboxyl-activated peptides in “80S” microsomal RNP particles of the same yeast.

3. 3. The possible relation of the activated peptide compounds to cytoplasmic protein synthesis is discussed.