Endorectal Brachytherapy Boost After External Beam Radiation Therapy in Elderly or Medically Inoperable Patients With Rectal Cancer: Primary Outcomes of the Phase 1 HERBERT Study
Publication date
2017-07
Authors
Rijkmans, Eva C.
Cats, Annemieke
Nout, Remi A.
Van den Bongard, Desiree
Ketelaars, Martijn
Buijsen, Jeroen
Rozema, Tom
Franssen, Jan Huib
Velema, Laura A.
van Triest, Baukelien
Editors
Advisors
Supervisors
Document Type
Article
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taverne
Abstract
Purpose: To evaluate the toxicity and efficacy of the combination of external beam radiation therapy (EBRT) followed by high-dose-rate endorectal brachytherapy (HDREBT) boost in elderly and medically inoperable patients with rectal cancer. Methods and Materials: A phase 1 dose-escalation study was performed. Treatment consisted of EBRT (13 × 3 Gy) followed by 3 weekly brachytherapy applications 6 weeks later. The HDREBT dose started at 5 Gy per fraction, increasing with 1 Gy per fraction if dose-limiting toxicity (DLT, defined as grade ≥3 proctitis
Keywords
Taverne, Radiation, Oncology, Radiology Nuclear Medicine and imaging, Cancer Research, Journal Article, Clinical Trial, Phase I
Citation
Rijkmans, E C, Cats, A, Nout, R A, van den Bongard, D, Ketelaars, M, Buijsen, J, Rozema, T, Franssen, J H, Velema, L A, van Triest, B & Marijnen, C A M 2017, 'Endorectal Brachytherapy Boost After External Beam Radiation Therapy in Elderly or Medically Inoperable Patients With Rectal Cancer : Primary Outcomes of the Phase 1 HERBERT Study', International Journal of Radiation Oncology Biology Physics, vol. 98, no. 4, pp. 908-917. https://doi.org/10.1016/j.ijrobp.2017.01.033