Structural and Functional Characterization of the Newly Designed Antimicrobial Peptide Crabrolin21
Publication date
2023-03
Authors
Cantini, Francesca
Giannì, Paola
Bobone, Sara
Troiano, Cassandra
van Ingen, Hugo
Massoud, Renato
Perini, Nicoletta
Migliore, Luciana
Savarin, Philippe
Sanders, Charles
Editors
Advisors
Supervisors
Document Type
Article
Metadata
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Abstract
(1) Background: antimicrobial resistance is becoming a dramatic problem for public health, and the design of new antimicrobial agents is an active research area. (2) Methods: based on our previous work, we designed an improved version of the crabrolin peptide and characterized its functional and structural properties with a wide range of techniques. (3) Results: the newly designed peptide, crabrolin21, is much more active than the previous ones and shows specific selectivity towards bacterial cells. (4) Conclusions: crabrolin21 shows interesting properties and deserves further studies.
Keywords
antimicrobial resistance, CD spectroscopy, membrane specificity, NMR spectroscopy, Chemical Engineering (miscellaneous), Process Chemistry and Technology, Filtration and Separation, SDG 3 - Good Health and Well-being
Citation
Cantini, F, Giannì, P, Bobone, S, Troiano, C, van Ingen, H, Massoud, R, Perini, N, Migliore, L, Savarin, P, Sanders, C, Stella, L & Sette, M 2023, 'Structural and Functional Characterization of the Newly Designed Antimicrobial Peptide Crabrolin21', Membranes, vol. 13, no. 3, 365, pp. 1-13. https://doi.org/10.3390/membranes13030365