Feasibility and safety of single-fraction sub-ablative radiotherapy with systemic therapy in colorectal cancer patients with ≤ 10 metastases: A multicenter pilot study (NCT05375708)
Publication date
2024-11
Authors
Zwart, Koen
Braat, M N G J A
van der Baan, Frederieke H
May, Anne M
Roodhart, Jeanine M.L.
Al-Toma, Dania
Otten, J. M.M.B.
Los, Maartje
Oostergo, T.
Fijneman, R. J.A.
Editors
Advisors
Supervisors
Document Type
Article
Metadata
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License
cc_by_nc_nd
Abstract
Colorectal cancer patients with ≤10 unresectable metastases were treated with single-fraction sub-ablative radiotherapy in addition to standard of care systemic therapy in a single-arm, open-label, multicenter, pilot study (SIRIUS) to assess feasibility and safety. Results indicate that radiotherapy combined with systemic therapy is feasible and safe in this population.
Keywords
Oligometastases, phase I, SBRT, Single fraction, Systemic therapy, Oncology, Radiology Nuclear Medicine and imaging
Citation
Zwart, K, Braat, M N G J A, van der Baan, F H, May, A M, Roodhart, J M L, Al-Toma, D, Otten, J M M B, Los, M, Oostergo, T, Fijneman, R J A, van Dodewaard-de Jong, J M, Punt, C J A, Meijer, G, Lagendijk, J J W, Koopman, M, Intven, M & Bol, G M 2024, 'Feasibility and safety of single-fraction sub-ablative radiotherapy with systemic therapy in colorectal cancer patients with ≤ 10 metastases : A multicenter pilot study (NCT05375708)', Clinical and translational radiation oncology, vol. 49, 100874, pp. 1-5. https://doi.org/10.1016/j.ctro.2024.100874