Prevotella timonensis Bacteria Associated With Vaginal Dysbiosis Enhance Human Immunodeficiency Virus Type 1 Susceptibility Of Vaginal CD4+ T Cells
Publication date
2024-07-15
Authors
van Teijlingen, NH
van Smoorenburg, MY
Sarrami-Forooshani, R
Zijlstra-Willems, EM
van Hamme, JL
Borgdorff, H
van de Wijgert, JHHM
van Leeuwen, E
van der Post, JAM
Strijbis, Karin
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Supervisors
Document Type
Article
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Abstract
Dysbiosis of the vaginal microbiome poses a serious risk for sexual human immunodeficiency virus type 1 (HIV-1) transmission. Prevotella spp are abundant during vaginal dysbiosis and associated with enhanced HIV-1 susceptibility; however, underlying mechanisms remain unclear. Here, we investigated the direct effect of vaginal bacteria on HIV-1 susceptibility of vaginal CD4(+) T cells. Notably, pre-exposure to Prevotella timonensis enhanced HIV-1 uptake by vaginal T cells, leading to increased viral fusion and enhanced virus production. Pre-exposure to antiretroviral inhibitors abolished P timonensis-enhanced infection. Our study shows that the vaginal microbiome directly affects mucosal CD4(+) T-cell susceptibility, emphasizing importance of vaginal dysbiosis diagnosis and treatment.
Keywords
CD4(+) T cells, HIV-1 susceptibility, Microbiome, Prevotella timonensis, Vaginal dysbiosis, SDG 3 - Good Health and Well-being
Citation
van Teijlingen, NH, van Smoorenburg, MY, Sarrami-Forooshani, R, Zijlstra-Willems, EM, van Hamme, JL, Borgdorff, H, van de Wijgert, JHHM, van Leeuwen, E, van der Post, JAM, Strijbis, K, Ribeiro, CMS & Geijtenbeek, TBH 2024, 'Prevotella timonensis Bacteria Associated With Vaginal Dysbiosis Enhance Human Immunodeficiency Virus Type 1 Susceptibility Of Vaginal CD4+ T Cells', Journal of Infectious Diseases, vol. 230, no. 1, pp. e43-e47. https://doi.org/10.1093/infdis/jiae166