Ligand-free copper-catalyzed C−S coupling of aryl iodides and thiols
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Publication date
2008
Authors
Sperotto, E.
van Klink, Gerard P.M.
de Vries, J.G.
van Koten, G.
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Abstract
A protocol for the copper-catalyzed aryl−sulfur bond formation between aryl iodides and thiophenols is reported. The reaction is catalyzed by a low amount (1−2.5 mol %) of readily available and ligand-free copper iodide salt. A variety of diaryl thioethers are synthesized under relatively mild reaction conditions with good chemoselectivity and functional group tolerance.
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Sperotto, E, van Klink, G P M, de Vries, J G & van Koten, G 2008, 'Ligand-free copper-catalyzed C−S coupling of aryl iodides and thiols', Journal of Organic Chemistry, vol. 73, no. 14, pp. 5625-5628.