Cytokine profiles in multifocal motor neuropathy and progressive muscular atrophy
Publication date
2015-09-15
Authors
Vlam, L
Stam, M
de Jager, Wilco
Cats, Elisabeth A.
van den Berg, Leonard
van der Pol, W Ludo
Editors
Advisors
Supervisors
Document Type
Article
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taverne
Abstract
Multifocal motor neuropathy (MMN) and progressive muscular atrophy (PMA) are associated with IgM monoclonal gammopathy or the presence IgM anti-GM1-antibodies. To further investigate the pathophysiology of MMN and PMA we determined concentrations of 16 mainly B-cell associated inflammatory markers in serum from 25 patients with MMN, 55 patients with PMA, 25 patients with amyotrophic lateral sclerosis (ALS) and 50 healthy controls. Median serum concentrations of the 16 tested cytokines and chemokines were not significantly increased in patients with MMN or patients with PMA, irrespective of the presence of IgM monoclonal gammopathy or high IgM anti-GM1 antibodies. These results argue against a systemic B-cell mediated immune response underlying the pathogenesis of MMN and PMA.
Keywords
Adult, Aged, Aged, 80 and over, Amyotrophic Lateral Sclerosis, Autoantibodies, B-Cell Activating Factor, Chi-Square Distribution, Cytokines, Enzyme-Linked Immunosorbent Assay, Female, G(M1) Ganglioside, Humans, Immunoglobulin M, Male, Middle Aged, Muscular Atrophy, Spinal, Polyneuropathies, Statistics, Nonparametric, Taverne, Journal Article, Research Support, Non-U.S. Gov't
Citation
Vlam, L, Stam, M, de Jager, W, Cats, E A, van den Berg, L H & van der Pol, W L 2015, 'Cytokine profiles in multifocal motor neuropathy and progressive muscular atrophy', Journal of Neuroimmunology, vol. 286, pp. 1-4. https://doi.org/10.1016/j.jneuroim.2015.06.008