Molecular Pathways Governing the Termination of Liver Regeneration
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Publication date
2024-05
Authors
de Haan, Lianne R.
van Golen, Rowan F.
Heger, Michal
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Supervisors
Document Type
Article
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taverne
Abstract
The liver has the unique capacity to regenerate, and up to 70% of the liver can be removed without detrimental consequences to the organism. Liver regeneration is a complex process involving multiple signaling networks and organs. Liver regeneration proceeds through three phases: the initiation phase, the growth phase, and the termination phase. Termination of liver regeneration occurs when the liver reaches a liver-to-body weight that is required for homeostasis, the so-called “hepatostat.” The initiation and growth phases have been the subject ofmany studies. Themolecular pathways that govern the termination phase, however, remain to be fully elucidated.
Keywords
Activated-receptor-gamma, Ccaat/enhancer-binding-protein, Glycogen-synthase kinase-3, Growth-factor-beta, Hsp90 inhibitor auy922, I dose-escalation, Portal-vein ligation, Retaspimycin hydrochloride ipi-504, Shock-protein 90, Tumor-necrosis-factor, Taverne
Citation
de Haan, L R, van Golen, R F & Heger, M 2024, 'Molecular Pathways Governing the Termination of Liver Regeneration', Pharmacological Reviews, vol. 76, no. 3, pp. 500-558. https://doi.org/10.1124/pharmrev.123.000955