A layered approach of response to treatment in Psoriasis and Psoriatic Arthritis

Abstract

Psoriasis is a chronic skin condition affecting approximately 60 million people worldwide, significantly impacting their lives. Its origins are complex, involving genetic and environmental factors, as well as immune system issues. Treatment is challenging and requires a multidisciplinary approach. Tofacitinib, a new medicine, appears effective in patients with higher IFN-γ levels. Systemic corticosteroids may be a safe option, contrary to previous concerns. The research also sheds light on predictive factors for methotrexate treatment in psoriatic arthritis and atopic eczema. These findings could pave the way for personalized treatments and contribute to understanding complex conditions like psoriasis and psoriatic arthritis.