Optimizing MR-Guided Radiotherapy for Breast Cancer Patients
Publication date
2020-07-28
Authors
Groot Koerkamp, Maureen
Vasmel, Jeanine E
Russell, Nicola S.
Shaitelman, Simona F.
Anandadas, Carmel N.
Currey, Adam
Vesprini, Danny
Keller, Brian M.
De-Colle, Chiara
Han, Kathy
Editors
Advisors
Supervisors
Document Type
Article
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Abstract
Current research in radiotherapy (RT) for breast cancer is evaluating neoadjuvant as opposed to adjuvant partial breast irradiation (PBI) with the aim of reducing the volume of breast tissue irradiated and therefore the risk of late treatment-related toxicity. The development of magnetic resonance (MR)–guided RT, including dedicated MR-guided RT systems [hybrid machines combining an MR scanner with a linear accelerator (MR-linac) or 60Co sources], could potentially reduce the irradiated volume even further by improving tumour visibility before and during each RT treatment. In this position paper, we discuss MR guidance in relation to each step of the breast RT planning and treatment pathway, focusing on the application of MR-guided RT to neoadjuvant PBI.
Keywords
MR-guided radiotherapy, MR-linac, breast cancer, hybrid machine, magnetic resonance imaging (MRI), neoadjuvant radiation therapy, partial breast irradiation, Oncology, Cancer Research, Review, Journal Article
Citation
Koerkamp, M L G, Vasmel, J E, Russell, N S, Shaitelman, S F, Anandadas, C N, Currey, A, Vesprini, D, Keller, B M, De-Colle, C, Han, K, Braunstein, L Z, Mahmood, F, Lorenzen, E L, Philippens, M E P, Verkooijen, H M, Lagendijk, J J W, Houweling, A C, van den Bongard, H J G D & Kirby, A M 2020, 'Optimizing MR-Guided Radiotherapy for Breast Cancer Patients', Frontiers in oncology, vol. 10, 1107, pp. 1107. https://doi.org/10.3389/fonc.2020.01107