Serum cytokine patterns in immunoglobulin m monoclonal gammopathy-associated polyneuropathy
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Publication date
2019-06
Authors
Stork, Abraham C J
Rijkers, Ger T
Vlam, L
Cats, Elisabeth A.
de Jong, Ben A W
Fritsch-Stork, Ruth D E
Veldink, Jan
van den Berg, Leonard
Notermans, Nicolette C.
van der Pol, W Ludo
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Article
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taverne
Abstract
Introduction: Polyneuropathy with immunoglobulin M monoclonal gammopathy (IgM-PNP) is associated with the presence of IgM antibodies against nerve constituents such as myelin associated glycoprotein (MAG) and gangliosides. Methods: To test whether B-cell-stimulating cytokines are increased in IgM-PNP, we measured serum concentrations of 11 cytokines in 81 patients with IgM-PNP and 113 controls. Results: Median interleukin (IL)-6 concentrations were higher in patients with IgM-PNP, and median IL-10 concentrations were higher in the subgroup with anti-MAG IgM antibodies. These serum concentrations were not increased in 110 patients with multifocal motor neuropathy. Discussion: Median IL-6 and IL-10 serum concentrations differ between patients with anti-MAG neuropathy and other patients with IgM-PNP compared with healthy and neuropathy controls. These differences may indicate differences in immune-mediated disease mechanisms. Muscle Nerve 59:694–698, 2019.
Keywords
anti-MAG neuropathy, cytokines, monoclonal gammopathy, multifocal motor neuropathy, peripheral neuropathy, Immunoglobulin M/immunology, Humans, Middle Aged, Cytokines/immunology, Male, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating/immunology, Interleukin-2/immunology, Interferon-gamma/immunology, Interleukin-6/immunology, Polyneuropathies/immunology, Aged, 80 and over, Interleukin-10/immunology, Adult, Female, Paraproteinemias/immunology, Myelin-Associated Glycoprotein/immunology, Interleukin-12/immunology, Autoantibodies/immunology, Interleukin-4/immunology, Interleukin-8/immunology, Tumor Necrosis Factor-alpha/immunology, B-Lymphocytes/immunology, Granulocyte-Macrophage Colony-Stimulating Factor/immunology, Aged, Taverne, Clinical Neurology, Physiology (medical), Cellular and Molecular Neuroscience, Physiology, Journal Article
Citation
Stork, A C J, Rijkers, G T, Vlam, L, Cats, E A, de Jong, B A W, Fritsch-Stork, R D E, Veldink, J H, van den Berg, L H, Notermans, N C & van der Pol, W-L 2019, 'Serum cytokine patterns in immunoglobulin m monoclonal gammopathy-associated polyneuropathy', Muscle & Nerve, vol. 59, no. 6, pp. 694-698. https://doi.org/10.1002/mus.26462