Moleculaire reclassificatie van chronisch inflammatoire aandoeningen voor personalized medicine. Feit of fictie?

Abstract

In this article, some aspects of toothpastes and contact Psoriatic arthritis (PsA) is currently under diagnosed and often resistant to treatment with traditional antirheumatic drugs, leading to increased morbidity and mortality. The UMC Utrecht has a specialized psoriasis clinic run by dermatologists en rheumatologists in which all patients are screened for psoriatic arthritis. This joint effort allows for performing meaningful, translation research. Indeed, the pathogenesis of PsA is not fully understood but thought to arise from the combination of genetic, epigenetic, and environmental factors. The socalled "systems medicine approach" uses high throughput technologies to help unravel the complex interactions between all these factors in order to better understand the specific pathways leading to this disease. The aim is to identify new diagnostic and prognostic biomarkers and novel therapeutic targets.