Targeting the TLR4-MD2 axis in systemic sclerosis
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Publication date
2018-10
Authors
O'Reilly, Steven
van Laar, J M
Editors
Advisors
Supervisors
Document Type
Editorial
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taverne
Abstract
Inappropriate activation of Toll-like receptor 4 (TLR4) on resident fibroblasts, through the binding of damage-associated molecular patterns, is a potential driver of fibrosis in systemic sclerosis. New evidence suggests that targeting fibroblast-specific TLR4 or an accessory molecule MD2 could have therapeutic value.
Keywords
Fibroblasts, Fibrosis, Humans, Lipopolysaccharides, Scleroderma, Systemic, Skin, Toll-Like Receptor 4, Taverne, Rheumatology, Comment, Journal Article
Citation
O'Reilly, S & van Laar, J M 2018, 'Targeting the TLR4-MD2 axis in systemic sclerosis', Nature Reviews. Rheumatology, vol. 14, no. 10, e98850, pp. 564-566. https://doi.org/10.1038/s41584-018-0077-6