Intrafraction motion analysis in online adaptive radiotherapy for esophageal cancer
Publication date
2023-04
Authors
Boekhoff, Mick R
Lagendijk, J J W
van Lier, Astrid L H M W
Mook, S
Meijer, Gert J
Editors
Advisors
Supervisors
Document Type
Article
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Abstract
Intrafraction motion during magnetic resonance (MR)-guided dose delivery of esophageal cancer tumors was retrospectively analyzed. Deformable image registration of cine-MR series resulted in gross tumor volume motion profiles in all directions, which were subsequently filtered to isolate respiratory and drift motion. A large variability in intrafraction motion patterns was observed between patients. Median 95% peak-to-peak motion was 7.7 (3.7 - 18.3) mm, 2.1 (0.7 - 5.7) mm and 2.4 (0.5 - 5.6) mm in cranio-caudal, left-right and anterior-posterior directions, relatively. Furthermore, intrafraction drift was generally modest (<5mm). A patient specific approach could lead to very small margins (<3mm) for most patients.
Keywords
Esophageal cancer, Intrafraction motion analysis, MR-Linac, MRgRT, Radiotherapy, Radiation, Oncology, Radiology Nuclear Medicine and imaging, Journal Article
Citation
Boekhoff, M R, Lagendijk, J J W, van Lier, A L H M W, Mook, S & Meijer, G J 2023, 'Intrafraction motion analysis in online adaptive radiotherapy for esophageal cancer', Physics and Imaging in Radiation Oncology, vol. 26, 100432, pp. 1-4. https://doi.org/10.1016/j.phro.2023.100432