Reactivation of Multidrug-Resistant HSV-1 in a Post-Allogenic Hematopoietic Stem Cell Transplant Patient: Dynamic Detection of the Rare A605V Mutation by Next-Generation Sequencing
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Publication date
2024-05-01
Authors
Zheng, Shuxuan
Rümke, Lidewij
Tello Rubio, Bruno
Rogers, Malbert
Van Sluis, Geerte L
Kuball, Jurgen
Riezebos-Brilman, A.
Lebbink, Robert Jan
Verduyn Lunell, F
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Abstract
We present an immunocompromised patient with a multiresistant herpes simplex virus-1 reactivation with a rare mutation (A605V) in the viral DNA polymerase gene. Next-generation sequencing suggests the presence of multiple drug-resistant strains before treatment and altered ratios during treatment, affecting the clinical response to aciclovir and foscarnet.
Keywords
aciclovir, foscarnet, HSV-1, multidrug resistance, stem cell transplantation, Oncology, Infectious Diseases
Citation
Zheng, S, Rümke, L L W, Tello Rubio, B, Rogers, M R C, Van Sluis, G L, Kuball, J H E, Riezebos-Brilman, A, Lebbink, R J & Verduyn Lunel, F M 2024, 'Reactivation of Multidrug-Resistant HSV-1 in a Post-Allogenic Hematopoietic Stem Cell Transplant Patient : Dynamic Detection of the Rare A605V Mutation by Next-Generation Sequencing', Open Forum Infectious Diseases, vol. 11, no. 5, ofae250. https://doi.org/10.1093/ofid/ofae250