The function of conducting a direct replication may be different than typically assumed: understanding contextuality and asymmetry

Publication date

2025-07

Authors

Meirmans, Stephanie
Luijken, KimORCID 0000-0001-5192-8368
Bruijning-Verhagen, P. C.J.L.ORCID 0000-0003-4105-9669ISNI 0000000419559955
Groenwold, Rolf H H
de Boer, Annemarijn R.ORCID 0000-0003-4200-0917

Editors

Advisors

Supervisors

Document Type

Article
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Abstract

Direct replication, that is, analysis of new data with the same study protocol, has a purpose in checking the reliability of earlier research findings. However, using a case study we show that direct replication can have an additional function. We find that identical numerical replication results can be the result of differential effects of biases across different data sources and we draw attention to the risk of asymmetric evaluation in such cases. We then show how exact replications have the important function to bring into focus the contextualities inherent in the generation of research findings. Understanding the contextuality allows for a better and richer understanding of what the results imply.

Keywords

Asymmetry, Contextuality, Reliability, Replicability, Replication crisis, Reproducibility, Validity, Epidemiology, Journal Article

Citation

Meirmans, S, Luijken, K, Bruijning-Verhagen, P C J L, Groenwold, R H H & de Boer, A R 2025, 'The function of conducting a direct replication may be different than typically assumed : understanding contextuality and asymmetry', Journal of Clinical Epidemiology, vol. 183, 111785. https://doi.org/10.1016/j.jclinepi.2025.111785