Mimicking the Articular Joint with In Vitro Models
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Publication date
2019-10
Authors
Piluso, Susanna
Li, Yang
Abinzano, Florencia
Levato, Riccardo
Moreira Teixeira, Liliana
Karperien, Marcel
Leijten, Jeroen
van Weeren, René
Malda, Jos
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Document Type
Article
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taverne
Abstract
Treating joint diseases remains a significant clinical challenge. Conventional in vitro cultures and animal models have been helpful, but suffer from limited predictive power for the human response. Advanced models are therefore required to mimic the complex biological interactions within the human joint. However, the intricate structure of the joint microenvironment and the complex nature of joint diseases have challenged the development of in vitro models that can faithfully mimic the in vivo physiological and pathological environments. In this review, we discuss the current in vitro models of the joint and the progress achieved in the development of novel and potentially more predictive models, and highlight the application of new technologies to accurately emulate the articular joint.
Keywords
organ-on-chip, biofabrication, microfluidics, synovium, inflammation, homeostasis, Taverne, SDG 3 - Good Health and Well-being
Citation
Piluso, S, Li, Y, Abinzano, F, Levato, R, Moreira Teixeira, L, Karperien, M, Leijten, J, van Weeren, R & Malda, J 2019, 'Mimicking the Articular Joint with In Vitro Models', Trends in Biotechnology, vol. 37, no. 10, pp. 1063-1077. https://doi.org/10.1016/j.tibtech.2019.03.003