Regional Chemotherapy of the Lung: Investigations of Isolated Lung Perfusion and Selective Pulmonary Artery Perfusion

Abstract

The aim of this thesis was two-fold. First, - part I of the dissertation -, to explore ILuP with melphalan and hyperthermia followed by pulmonary metastasectomy in patients with resectable pulmonary metastases. Second, - part II -, to investigate the feasibility and pharmacokinetics of SPAP with gemcitabine, studied in a tumor-free porcine model.