ATRP, subsequent azide substitution and 'click' chemistry: Three reactions using one catalyst in one pot
Publication date
2011-07-05
Authors
De Graaf, Albert J.
Mastrobattista, Enrico
van Nostrum, Cornelus F
Rijkers, Dirk T S
Hennink, Wim E.
Vermonden, Tina
Editors
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Supervisors
Document Type
Article
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Abstract
This communication describes a novel and fast reaction to substitute the living chain end after Atom Transfer Radical Polymerization (ATRP) by an azide functionality. The reaction is catalyzed by the ATRP catalyst at room temperature in aqueous solution and can be followed by a 'click' reaction using again the same catalyst.
Keywords
Farmacie/Biofarmaceutische wetenschappen (FARM), Medical technology, Farmacie(FARM), Biomedische technologie en medicijnen, Pharmacology, Taverne, Catalysis, Electronic, Optical and Magnetic Materials, Ceramics and Composites, General Chemistry, Surfaces, Coatings and Films, Metals and Alloys, Materials Chemistry
Citation
De Graaf, A J, Mastrobattista, E, Van Nostrum, C F, Rijkers, D T S, Hennink, W E & Vermonden, T 2011, 'ATRP, subsequent azide substitution and 'click' chemistry : Three reactions using one catalyst in one pot', Chemical Communications, vol. 47, no. 24, pp. 6972-6974. https://doi.org/10.1039/c1cc12224j