A Poorest-First Approach to RSV Vaccine Development

Abstract

The principle aim of this thesis was to use a multidisciplinary approach to establish the foundations for an RSV vaccine in lower and lower-middle income countries (LMICs). Four different approaches were used: (1) Global epidemiology: to understand the age distribution for life-threatening RSV (2) Translational medicine: to understand protection through mucosal antibody transfer (3) Clinical development: to provide an overview of the RSV vaccine pipeline (4) Ethics: to analyze the ethical framework of post-trial access for RSV vaccine trials