Assessment of the antiviral properties of recombinant surfactant protein D against influenza B virus in vitro
Files
Publication date
2015
Authors
Hillaire, M.L.B.
van Eijk, Martin
Vogelzang-van Trierum, Stella E
Nieuwkoop, Nella J
van Riel, Debby
Fouchier, Ron A M
Kuiken, Thijs
Osterhaus, Albert D.M.E.
Haagsman, Henk P
Rimmelzwaan, Guus F
Editors
Advisors
Supervisors
Document Type
Article
Metadata
Show full item recordCollections
License
taverne
Abstract
The armamentarium of antiviral drugs against influenza viruses is limited. Furthermore, influenza viruses emerge that are resistant to existing antiviral drugs like the M2 and NA inhibitors. Therefore, there is an urgent need for the development of novel classes of antiviral drugs. Here we investigated the antiviral properties of recombinant porcine surfactant protein D (RpSP-D), an innate defense molecule with lectin properties, against influenza B viruses. We have previously shown that porcine SP-D has more potent neutralizing activity against influenza A viruses than human SP-D. Here we show that RpSP-D neutralizes influenza B viruses efficiently and inhibited the binding of these viruses to epithelial cells of the human trachea.
Keywords
Antiviral, Influenza, Surfactant protein D, Taverne
Citation
Hillaire, M L B, van Eijk, M, Vogelzang-van Trierum, S E, Nieuwkoop, N J, van Riel, D, Fouchier, R A M, Kuiken, T, Osterhaus, A D M E, Haagsman, H P & Rimmelzwaan, G F 2015, 'Assessment of the antiviral properties of recombinant surfactant protein D against influenza B virus in vitro', Virus Research, vol. 195, pp. 43-46. https://doi.org/10.1016/j.virusres.2014.08.019