Diagnostic accuracy of [ 99mTc]Tc-tilmanocept compared to [ 99mTc]Tc-nanocolloid for sentinel lymph node identification in early-stage oral cancer
Publication date
2021-11
Authors
Mahieu, Rutger
den Toom, Inne J.
van Rooij, Rob
van Es, Robert J J
Hobbelink, M. G G
Krijger, Gerard C.
Tijink, Bernard M
de Keizer, Bart
de Bree, Remco
Editors
Advisors
Supervisors
Document Type
Letter
Metadata
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License
taverne
Abstract
This study compares sentinel lymph node identification using [99m Tc]Tc-tilmanocept to [99m Tc]Tc-nanocolloid in early-stage oral cancer patients In those who underwent lymphoscintigraphy using both radiotracers, presence of nodal metastasis was correctly identified by either radiotracer Sentinel lymph node biopsy using [99mTc]Tc-tilmanocept reached a sensitivity of 83.3% and negative predictive value of 93.3% Accuracy of sentinel lymph node biopsy using [99mTc]Tc-tilmanocept is comparable to using [99mTc]Tc-nanocolloid Tilmanocept may be an alternative for nanocolloid in sentinel lymph node biopsy.
Keywords
Lymph Node, Lymphoscintigraphy, metastasis, oral cancer, sentinel lymph node biopsy, [ Tc]Tc-tilmanocept, Taverne, Otorhinolaryngology, Letter
Citation
Mahieu, R, den Toom, I J, van Rooij, R, van Es, R J J, Hobbelink, M G G, Krijger, G C, Tijink, B M, de Keizer, B & de Bree, R 2021, 'Diagnostic accuracy of [ 99m Tc]Tc-tilmanocept compared to [ 99m Tc]Tc-nanocolloid for sentinel lymph node identification in early-stage oral cancer', Clinical Otolaryngology, vol. 46, no. 6, pp. 1383-1388. https://doi.org/10.1111/coa.13798