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Getting the genome in shape: the formation of loops, domains and compartments

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shape.pdf (1.2 MB)

Publication date

2015

Authors

Bouwman, Britta A M
de Laat, WouterISNI 0000000388639337

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DOI

https://doi.org/10.1186/s13059-015-0730-1

Document Type

Article

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Abstract

The hierarchical levels of genome architecture exert transcriptional control by tuning the accessibility and proximity of genes and regulatory elements. Here, we review current insights into the trans-acting factors that enable the genome to flexibly adopt different functionally relevant conformations.

Keywords

Journal Article, Research Support, Non-U.S. Gov't, Review

Citation

Bouwman, B A M & de Laat, W 2015, 'Getting the genome in shape : the formation of loops, domains and compartments', Genome Biology, vol. 16, no. 154. https://doi.org/10.1186/s13059-015-0730-1

URI

https://dspace.library.uu.nl/handle/1874/333240