Preventing ventriculostomy-related infections with antibiotic-impregnated drains in hospitals: a two-centre Dutch study
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Publication date
2016-04-01
Authors
Verberk, Janneke
Berkelbach van der Sprenkel, Jan Willem
Arts, M. P.
Dennesen, P. J W
Bonten, Marc
Van Mourik, Maaike S M
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Supervisors
Document Type
Letter
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taverne
Abstract
This observational cohort study assessed the effect of the introduction of antibiotic-impregnated external ventricular drains (AI-EVDs), as opposed to plain silicone EVDs, on the occurrence of ventriculostomy-related infections (VRIs) in two Dutch hospitals, with no other changes to their clinical practice. VRI was defined using the criteria of the Centers for Disease Control and Prevention, and with a culture-based definition. A propensity-score-adjusted competing risks survival analysis showed that introduction of AI-EVDs did not significantly decrease the risk of VRIs in routine care, nor affect the bacterial aetiology, even after adjustment for confounding and competing events.
Keywords
Antibiotic-impregnated, Competing risks, External ventricular drains, Neurosurgery, Survival, Ventriculostomy-related infection, Taverne, Microbiology (medical), Infectious Diseases
Citation
Verberk, J D M, Berkelbach vd Sprenkel, J W, Arts, M P, Dennesen, P J W, Bonten, M J M & van Mourik, M S M 2016, 'Preventing ventriculostomy-related infections with antibiotic-impregnated drains in hospitals : a two-centre Dutch study', The journal of Hospital Infection, vol. 92, no. 4, pp. 401-404. https://doi.org/10.1016/j.jhin.2015.12.018