Further investigations on the macromolecular complex in human bile

Abstract

The formation of complexes in human bile was further studied by the preparation of various synthetic complexes and extracts. These were compared for a number of properties with the natural complex of human gall bladder bile. It appeared that protein is probably and bilirubin quite definitely a constituent of the natural complex. Small quantities of the complex or related substances could be detected in fistula bile. Complex formation begins in the fistula bile, but in the gall bladder the conditions for complex formation are optimal. The phenomena cannot be explained by concentration of the hepatic bile alone.