Sweet attachment: Structural and functional studies on nidovirus hemagglutinin-esterases

Abstract

The thesis described our investigations in the fields of O-acetylsialoglycobiology and the structure and function of corona- and torovirus hemagglutininesterase (HE) proteins. There are three topics that cover the experimental contents of this thesis: i) the distribution and synthesis of O-Ac-sialoglycans ii) common principles underlying the structural recognition of O-Ac-Sia by viral proteins iii) the dynamic balance of virionglycan interactions by the opposing activities of attachment and release.