Anthelmintics, used for the treatment of fascioliasis as uncouplers of oxidative phosphorylation in warm blooded animals
Publication date
1969-12
Authors
Miert, A.S.J.P.A.M. van
Groeneveld, H.W.
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DOI
Document Type
Article
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Abstract
Dinitrophenol and liverfluke anthelmintics such as niclofolan, nitroxynil, bromophenophos and hexachlorophene increased ATP-ase activity of rat-liver mitochondria and caused a contracture of striated muscle in vitro. After lethal doses, rigidity occured soon after deatth. It is postulated that these anthelmintics are potent uncouplers of oxidative phosphorylation in warm-blooded animals.
Keywords
Liver fluke anthelmintics, Uncoupling agents, Contracture of striated muscle, 2,4-dinitrophenol, ATP-ase liver mitochondria, Post-mortem rigidity