Interictal PET and Its Value in the Localization of the Seizure-Onset Zone
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Publication date
2026-04-01
Authors
Tolboom, N.
Meurs, Alfred
Van Weehaeghe, Donatienne
Editors
Van Roost, Dirk
Schijns, Olaf E. M. G.
Advisors
Supervisors
Document Type
Part of book
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taverne
Abstract
PET imaging enables, among others, noninvasive visualization of glucose metabolism using [18F]FDG. In focal epilepsy patients, the whole irritative zone is hypometabolic and called the functional deficit zone (FDZ). This is in contrast with the high physiological uptake in the surrounding healthy cortex. Interictal [18F]FDG PET can help to identify the seizure-onset zone both in temporal and extratemporal epilepsy. It plays a unique and important role in the presurgical workup for patients with drug-resistant epilepsy (DRE), more specifically in MRI-negative patients, when the MRI shows multiple lesions or when the MRI is discordant with other information such as the EEG or semiology. Moreover, it can provide prognostic information as surgical outcome is related to the extent of the hypometabolic zone beyond the seizure-onset zone.
Keywords
DPA714, FDG PET, Flumazenil, Functional deficit zone, Glucose metabolism, Hypometabolism, Seizure-onset zone detection, Surgery workup, Tracer, Translocator protein, Taverne, General Medicine, General Neuroscience
Citation
Tolboom, N, Meurs, A & Van Weehaeghe, D 2026, Interictal PET and Its Value in the Localization of the Seizure-Onset Zone. in D Van Roost & O E M G Schijns (eds), Controversies in Epilepsy Surgery : Minimally Invasive Techniques and Recent Developments. Springer, pp. 81-87. https://doi.org/10.1007/978-3-032-04182-1_8