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SIAPhos: Phosphorylated Sulfonimidamides and their Use in Iridium-Catalyzed Asymmetric Hydrogenations of Sterically Hindered Cyclic Enamides

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Publication date

2012

Authors

Patureau, F.W.
Worch, C.
Siegler, Maxime A.ISNI 0000000396450817
Spek, Anthony LouisISNI 0000000389231413
Bolm, C.
Reek, J.N.H.

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DOI

https://doi.org/10.1002/adsc.201100692

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Article

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Abstract

Phosphorylated sulfonimidamides (SIAPhos) undergo ion exchange reactions with cationic complexes, [Rh(cod)2BF4] and [Ir(cod)2BarF], or neutral complexes [Rh(cod)Cl]2 and [Ir(cod)Cl]2, leading to unprecedented neutral complexes with P-N-S-N chelates. Use of the resulting neutral iridium complexes in asymmetric hydrogenation reactions of tri- and tetrasubstituted enamides leads to products with high enantioselectivities (up to 92% ee).

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Citation

Patureau, F W, Worch, C, Siegler, M A M, Spek, A L, Bolm, C & Reek, J N H 2012, 'SIAPhos: Phosphorylated Sulfonimidamides and their Use in Iridium-Catalyzed Asymmetric Hydrogenations of Sterically Hindered Cyclic Enamides', Advanced Synthesis and Catalysis, vol. 354, no. 1, pp. 59-64. https://doi.org/10.1002/adsc.201100692

URI

http://hdl.handle.net/1874/269805