Influence of Mg2+, ITP4- and ATP4- on human platelet phosphofructokinase
Publication date
1974-11-25
Authors
Akkerman, Jan Willem N.
Gorter, Gertie
Sixma, J.J.
Staal, Gerard E.J.
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Abstract
In the reaction catalyzed by human platelet phosphofructokinase, Mg2+ is required for optimal activity. Maximal MG2− activation was obtained at [Mg2+] = [MgITP2−] or higher. At high MgATP2− concentrations there is an increase in the allosteric inhibition by ATP4−.