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Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities

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Modalities.pdf (1.84 MB)

Publication date

2017-06-01

Authors

Nusse, Roel
Clevers, HansISNI 0000000043961208

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DOI

https://doi.org/10.1016/j.cell.2017.05.016

Document Type

Article

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taverne

Abstract

The WNT signal transduction cascade is a main regulator of development throughout the animal kingdom. Wnts are also key drivers of most types of tissue stem cells in adult mammals. Unsurprisingly, mutated Wnt pathway components are causative to multiple growth-related pathologies and to cancer. Here, we describe the core Wnt/β-catenin signaling pathway, how it controls stem cells, and contributes to disease. Finally, we discuss strategies for Wnt-based therapies.

Keywords

cancer, development, stem cells, therapy, Wnt, Taverne, General Biochemistry,Genetics and Molecular Biology, Journal Article, Review

Citation

Nusse, R & Clevers, H 2017, 'Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities', Cell, vol. 169, no. 6, pp. 985-999. https://doi.org/10.1016/j.cell.2017.05.016

URI

https://dspace.library.uu.nl/handle/1874/352669