Circulating Extracellular Vesicles Contain miRNAs and are Released as Early Biomarkers for Cardiac Injury
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Publication date
2016-07-06
Authors
Deddens, Janine C
Vrijsen, Krijn R
Colijn, Johanna M
Oerlemans, Marish I F J
Metz, Corina H
van der Vlist, Els J
Nolte-'t Hoen, Esther N M
den Ouden, Krista
Jansen of Lorkeers, Sanne J.
van der Spoel, T.I.G.
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Article
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Abstract
Plasma-circulating microRNAs have been implicated as novel early biomarkers for myocardial infarction (MI) due to their high specificity for cardiac injury. For swift clinical translation of this potential biomarker, it is important to understand their temporal and spatial characteristics upon MI. Therefore, we studied the temporal release, potential source, and transportation of circulating miRNAs in different models of ischemia reperfusion (I/R) injury. We demonstrated that extracellular vesicles are released from the ischemic myocardium upon I/R injury. Moreover, we provided evidence that cardiac and muscle-specific miRNAs are transported by extracellular vesicles and are rapidly detectable in plasma. Since these vesicles are enriched for the released miRNAs and their detection precedes traditional damage markers, they hold great potential as specific early biomarkers for MI.
Keywords
Biomarkers, Circulating microRNA, Exosomes, Extracellular vesicles, Myocardial infarction, Cardiology and Cardiovascular Medicine, Genetics, Genetics(clinical), Molecular Medicine, Pharmaceutical Science, Journal Article
Citation
Deddens, J C, Vrijsen, K R, Colijn, J M, Oerlemans, M, Metz, C H G, van der Vlist, E J, Nolte-'t Hoen, E N M, den Ouden, K, Jansen of Lorkeers, SJ, van der Spoel, TIG, Koudstaal, S, Arkesteijn, G J, Wauben, M H M, van Laake, L W, Doevendans, P A, Chamuleau, S A J & Sluijter, J P G 2016, 'Circulating Extracellular Vesicles Contain miRNAs and are Released as Early Biomarkers for Cardiac Injury', Journal of Cardiovascular Translational Research, vol. 9, no. 4, pp. 291-301. https://doi.org/10.1007/s12265-016-9705-1