Cholesterol: fa(s)t-food for enterovirus genome replication
Publication date
2013
Authors
Strating, Jeroen R P M
van der Schaar, H.M.
van Kuppeveld, Frank J.M.
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Article
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Abstract
Hijacking and remodeling of host membranes is an obligatory step in the replicative cycle of (+)RNA viruses, including enteroviruses. Ilnytska et al. unveiled in Cell Host & Microbe that enteroviruses usurp clathrin-mediated endocytosis to shuttle cholesterol to sites of genome replication and that cholesterol is needed for efficient replication.
Keywords
Coronacrisis-Taverne
Citation
Strating, J R P M, van der Schaar, H M & van Kuppeveld, F J M 2013, 'Cholesterol: fa(s)t-food for enterovirus genome replication', Trends in Microbiology, vol. 21, no. 11, pp. 560-561. https://doi.org/10.1016/j.tim.2013.09.007