A hybrid polymer to target blood group dependence of cholera toxin
Publication date
2020-01-01
Authors
Haksar, Diksha
Quarles Van Ufford, Linda H C
Pieters, Roland J.
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Document Type
Article
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Abstract
Cholera is a potentially fatal bacterial infection caused by the cholera toxin (CT), an AB5 toxin secreted by Vibrio cholera. GM1 has long been known as the receptor of the cholera toxin in the intestine. However, increasing evidence is pointing towards the role of fucosylated conjugates as additional attachment options of the toxin. In the present paper we have synthesized a polymeric hybrid which can inhibit both modes of attachment.
Keywords
Biochemistry, Physical and Theoretical Chemistry, Organic Chemistry, SDG 3 - Good Health and Well-being
Citation
Haksar, D, Quarles Van Ufford, L & Pieters, R J 2020, 'A hybrid polymer to target blood group dependence of cholera toxin', Organic and Biomolecular Chemistry, vol. 18, no. 1, pp. 52-55. https://doi.org/10.1039/c9ob02369k