Lymphoblastic lymphoma with a triple-hit profile: a rare but distinct and relevant entity
Publication date
2017-05
Authors
Hiemcke-Jiwa, Laura S
Leguit, R J
van der Veken, Lars
Buijs, Arjan
Leeuwis, JW
de Boer, M. G. J.
Jiwa, Mehdi
Bloem, Andries C.
Clevers-Petersen, E.J.
de Weger, Roel A.
Editors
Advisors
Supervisors
Document Type
Article
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taverne
Abstract
Follicular lymphoma with progression to a high-grade lymphoma bears a poor prognosis. We describe a case of a 60-year-old man who presented in 2012 with an epidural mass, diagnosed as a diffuse large B-cell lymphoma (DLBCL) with concurrent low-grade follicular lymphoma. Three years later, the patient presented with a cervical mass, diagnosed as a lymphoblastic lymphoma (LBL). Both the DLBCL and LBL contained a “triple hit” with BCL2, BCL6, and cMYC translocations demonstrated by fluorescence in situ hybridization analysis and a complex karyotype by single-nucleotide polymorphism array analysis. Furthermore, the 2 lymphomas were shown to be clonally related by clonality analysis and single-nucleotide polymorphism array analysis. This case report presents a highly unusual case of an LBL with a triple hit, originating from a DLBCL, which has rarely been described in the literature and deserves further exploration.
Keywords
Complex karyotype, Lymphoblastic lymphoma, SNP array, Transformation, Triple hit, Taverne, Pathology and Forensic Medicine, Journal Article, Case Reports
Citation
Hiemcke-Jiwa, L S, Leguit, RJ, van der Veken, L T, Buijs, A, Leeuwis, JW, de Boer, M, Jiwa, M, Bloem, AC, Clevers-Petersen, E J, de Weger, R A & Huibers, M M H 2017, 'Lymphoblastic lymphoma with a triple-hit profile : a rare but distinct and relevant entity', Human Pathology, vol. 63, pp. 171-176. https://doi.org/10.1016/j.humpath.2016.11.002