In vivo deuterium labelling in mice supports a dynamic model for memory T-cell maintenance in the bone marrow
Publication date
2019-06
Authors
Baliu-Piqué, Mariona
Otto, Sigrid A.
Borghans, J.A.M.
Tesselaar, K.
Editors
Advisors
Supervisors
Document Type
Article
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taverne
Abstract
The maintenance and dynamics of memory T-cells in the bone marrow are a matter of ongoing debate. It has been suggested that memory T-cells in the bone marrow are maintained as long-lived, quiescent cells. We have recently shown that memory T-cells isolated from goat bone marrow undergo self-renewal and recirculate via the blood and lymph. Using the well-established memory T-cell markers CD44 and CD62L we here show very similar results in mice. This provides further support for the concept that memory T-cells are continuously self-renewing and recirculating between blood, bone marrow, spleen and lymph nodes.
Keywords
Bone marrow, Deuterium, Lymphocyte turnover, Mathematical modelling, Memory T-cells, Stable isotope labelling, Taverne, Immunology and Allergy, Immunology, Journal Article, Research Support, Non-U.S. Gov't
Citation
Baliu-Piqué, M, Otto, S A, Borghans, J A M & Tesselaar, K 2019, 'In vivo deuterium labelling in mice supports a dynamic model for memory T-cell maintenance in the bone marrow', Immunology Letters, vol. 210, pp. 29-32. https://doi.org/10.1016/j.imlet.2019.04.004