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Designing pragmatic trials—what can we learn from lessons learned?

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1_s2.0_S0895435617304596_main.pdf (130.37 KB)

Publication date

2017-10-01

Authors

Groenwold, RHHISNI 0000000394374611
Dekkers, Olaf M

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DOI

https://doi.org/10.1016/j.jclinepi.2017.06.006

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Comment

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Abstract

Pragmatic trials aim to inform clinical decision making by measuring the effect of a treatment in clinical practice. The purpose of the PRECIS-2 tool is to support in designing a truly pragmatic trial. We comment on a study by Forbes et al., who assessed the applicability of the PRECIS-2 tool. The tool will prove particularly useful when implemented in the process of trial design. However, it is yet unclear how e.g., possible dependencies between PRECIS domains, or conducting a pragmatic trial within an existing data registry (e.g., electronic health records) affect the applicability of the tool.

Keywords

Pragmatic trial, Randomised trial, Taverne, Epidemiology

Citation

Groenwold, R H H & Dekkers, O M 2017, 'Designing pragmatic trials—what can we learn from lessons learned?', Journal of Clinical Epidemiology, vol. 90, pp. 3-5. https://doi.org/10.1016/j.jclinepi.2017.06.006

URI

https://dspace.library.uu.nl/handle/1874/360188