A fluorescent, paramagnetic and PEGylated gold/silica nanoparticle for MRI, CT and fluorescence imaging
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Publication date
2010
Authors
van Schooneveld, M.M.
Cormode, D.P.
Koole, R.
van Wijngaarden, J.T.
Calcagno, C.
Skajaa, Torjus
Hilhorst, J.
't Hart, D.C.
Fayad, Z.A.
Mulder, Willem J M
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Abstract
An important challenge in medical diagnostics is to design all-in-one contrast agents that can be detected with multiple techniques such as magnetic resonance imaging (MRI), X-ray computed tomography (CT), positron emission tomography (PET), single photon emission tomography (SPECT) or fluorescence imaging (FI). Although many dual labeled agents have been proposed, mainly for combined MRI/FI, constructs for three imaging modalities are scarce. Here gold/silica nanoparticles with a poly(ethylene glycol), paramagnetic and fluorescent lipid coating were synthesized, characterized and applied as trimodal contrast agents to allow for nanoparticle-enhanced imaging of macrophage cells in vitro via MRI, CT and FI, and mice livers in vivo via MRI and CT. This agent can be a useful tool in a multitude of applications, including cell tracking and target-specific molecular imaging, and is a step in the direction of truly multi-modal imaging
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van Schooneveld, M M, Cormode, D P, Koole, R, van Wijngaarden, J T, Calcagno, C, Skajaa, T, Hilhorst, J, 't Hart, D C, Fayad, Z A, Mulder, W J M & Meijerink, A 2010, 'A fluorescent, paramagnetic and PEGylated gold/silica nanoparticle for MRI, CT and fluorescence imaging', Contrast Media & molecular imaging, vol. 5, no. 4, pp. 231-236. https://doi.org/10.1002/cmmi.376