Autoimmune disease-associated gene expression is reduced by BET-inhibition
Publication date
2016
Authors
Peeters, J.
Vervoort, Stephin
Mijnheer, Gerdien
de Roock, Sytze
Vastert, Sebastiaan J
Nieuwenhuis, Edward E.S.
van Wijk, Femke
Prakken, Berent
Mokry, Michal
van Loosdregt, Jorg
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Advisors
Supervisors
Document Type
Article
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Abstract
For many autoimmune diseases, the underlying mechanism is still unknown. In order to get more insight into the etiology of autoimmune diseases, we recently published a study were we performed epigenetic profiling and RNA sequencing on CD4(+)CD45RO(+) T cells derived from the site of inflammation of Juvenile Idiopathic Arthritis (JIA) patients and compared this with healthy controls [1]. In this "Data in Brief", we focus on the analysis of our RNA sequencing data reported in this study, of which the raw and processed files can be found in GEO under GSE71595. We provide a detailed description of the downstream analysis, quality controls, and different analysis methods or techniques that validate the results obtained with RNA-sequencing.
Keywords
Autoimmune disease, RNA-sequencing, Juvenile Idiopathic Arthritis, BET-inhibition, Journal Article
Citation
Peeters, J G C, Vervoort, S J, Mijnheer, G, de Roock, S, Vastert, S J, Nieuwenhuis, E E S, van Wijk, F, Prakken, B J, Mokry, M & van Loosdregt, J 2016, 'Autoimmune disease-associated gene expression is reduced by BET-inhibition', Genomics data, vol. 7, pp. 14-7. https://doi.org/10.1016/j.gdata.2015.11.004