Lactulose synergizes with CpG-ODN to modulate epithelial and immune cells cross talk
Publication date
2019-01-11
Authors
Mukherjee, Reshmi
van de Kaa, Melanie
Garssen, Johan
Pieters, Roland J.
Kraneveld, Aletta
Willemsen, Linette
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Abstract
Lactulose, a non-digestible oligosaccharide and functional food, promotes Bifidobacteria growth. Here we show that lactulose, beyond its prebiotic action, may have direct immunomodulatory effects as well. In synergy with CpG-ODN, a bacterial DNA mimetic, lactulose enhances basolateral concentrations of IFN-γ, IL-10, and galectin-9 in the co-culture model of epithelial and immune cells.
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Mukherjee, R, van de Kaa, M, Garssen, J, Pieters, R J, Kraneveld, A D & Willemsen, L E M 2019, 'Lactulose synergizes with CpG-ODN to modulate epithelial and immune cells cross talk', Food & function, vol. 10, no. 1, pp. 33-37. https://doi.org/10.1039/c8fo02376j