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The Upper Hand of the Otu Amyloid Fibers: Increasing Enzymatic Activity and Prolonging Lifespan

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Publication date

2019-04-18

Authors

Rabouille, CatherineISNI 0000000001502935

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DOI

https://doi.org/10.1016/j.molcel.2019.03.038

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Article

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taverne

Abstract

The formation of amyloid fibers is usually associated with aging and neurodegeneration. In this issue of Molecular Cell, Ji et al. (2019) demonstrate that the deubiquitinase Otu coalesces into amyloid-like fibers to enhance its activity and ensure its optimum biological function.

Keywords

Animals, Basic Helix-Loop-Helix Transcription Factors, Drosophila, Drosophila Proteins, Longevity, Taverne, Journal Article, Comment

Citation

Rabouille, C 2019, 'The Upper Hand of the Otu Amyloid Fibers : Increasing Enzymatic Activity and Prolonging Lifespan', Molecular Cell, vol. 74, no. 2, pp. 225-226. https://doi.org/10.1016/j.molcel.2019.03.038

URI

http://hdl.handle.net/1874/390554