Decay Rates of Maternal Tetanus, Diphtheria, and Pertussis Antibody Levels in Early and Moderate-to-Late Preterm and Term Infants at Birth and at Two Months
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Publication date
2025-01
Authors
Immink, Maarten M.
van der Maas, Nicoline A T
Bekker, Mireille N.
de Melker, Hester E
den Hartog, Gerco
Rots, Nynke Y
van Gageldonk, Pieter G M
Groenendaal, Floris
Sanders, Elisabeth A M
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Article
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Abstract
A post hoc analysis of maternally derived antibodies at birth and age 2 months following second trimester maternal Tdap vaccination between 20 and 24 weeks' gestational age (GA) showed a faster decay rate of Tdap-related immunoglobulin G in early preterms born before 32 weeks' GA compared with moderate-to-late preterms and full-terms. This is different from previous studies and merits further research.
Keywords
antibody decay, full-term, immunogenicity, maternal immunization, pertussis, preterm, Oncology, Infectious Diseases
Citation
Immink, M M, van der Maas, N A T, Bekker, M N, de Melker, H E, den Hartog, G, Rots, N Y, van Gageldonk, P G M, Groenendaal, F & Sanders, E A M 2025, 'Decay Rates of Maternal Tetanus, Diphtheria, and Pertussis Antibody Levels in Early and Moderate-to-Late Preterm and Term Infants at Birth and at Two Months', Open Forum Infectious Diseases, vol. 12, no. 1, ofae717. https://doi.org/10.1093/ofid/ofae717