Sex-Based Differences in Treatment with Immune Checkpoint Inhibition and Targeted Therapy for Advanced Melanoma: A Nationwide Cohort Study
Publication date
2021-09-16
Authors
van der Kooij, Monique K
Dekkers, Olaf M
Aarts, Maureen J B
van den Berkmortel, Franchette W P J
Boers-Sonderen, Marye J
de Groot, Jan Willem B
Hospers, Geke A P
Piersma, Djura
van Rijn, Rozemarijn S
Suijkerbuijk, Karijn P M
Editors
Advisors
Supervisors
Document Type
Article
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cc_by
Abstract
Recent meta-analyses show conflicting data on sex-dependent benefit following systemic treatment for advanced melanoma patients. We examined the nationwide Dutch Melanoma Treatment Registry (July 2013-July 2018), assessing sex-dependent differences in advanced melanoma patients (stage IIIC/IV) with respect to clinical characteristics, mutational profiles, treatments initiated, grade 3-4 adverse events (AEs), treatment responses, and mortality. We included 3985 patients, 2363 men (59%) and showed that although men and women with advanced melanoma differ in clinical and tumor characteristics, the safety profile of immune checkpoint inhibition (ICI) is comparable. The data suggest a 10% survival advantage for women, mainly seen in patients ≥60 years of age and patients with BRAF V600 mutant melanoma. Following ICI there was no survival difference.
Keywords
advanced melanoma, immunotherapy, prospective nation-wide data, sex, targeted therapy, Targeted therapy, Immunotherapy, Sex, Advanced melanoma, Prospective nation-wide data, Oncology, Cancer Research, Journal Article
Citation
van der Kooij, M K, Dekkers, O M, Aarts, M J B, van den Berkmortel, F W P J, Boers-Sonderen, M J, de Groot, J W B, Hospers, G A P, Piersma, D, van Rijn, R S, Suijkerbuijk, K P M, Westgeest, H M, van der Veldt, A A M, Vreugdenhil, G, Wilgenhof, S, Wouters, M W J M, Haanen, J B A G, van den Eertwegh, A J M & Kapiteijn, E 2021, 'Sex-Based Differences in Treatment with Immune Checkpoint Inhibition and Targeted Therapy for Advanced Melanoma : A Nationwide Cohort Study', Cancers, vol. 13, no. 18, 4639, pp. 1-13. https://doi.org/10.3390/cancers13184639