Nomenclature report for killer-cell immunoglobulin-like receptors (KIR) in macaque species: new genes/alleles, renaming recombinant entities and IPD-NHKIR updates
Publication date
2019-11-20
Authors
Bruijnesteijn, Jesse
de Groot, Natasja G.
Otting, Nel
Maccari, Giuseppe
Guethlein, Lisbeth A.
Robinson, James
Marsh, Steven G.E.
Walter, Lutz
O’Connor, David H.
Hammond, John A.
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Advisors
Supervisors
Document Type
Article
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Abstract
The Killer-cell Immunoglobulin-like Receptors (KIR) are encoded by a diverse group of genes, which are characterized by allelic polymorphism, gene duplications, and recombinations, which may generate recombinant entities. The number of reported macaque KIR sequences is steadily increasing, and these data illustrate a gene system that may match or exceed the complexity of the human KIR cluster. This report lists the names of quality controlled and annotated KIR genes/alleles with all the relevant references for two different macaque species: rhesus and cynomolgus macaques. Numerous recombinant KIR genes in these species necessitate a revision of some of the earlier-published nomenclature guidelines. In addition, this report summarizes the latest information on the Immuno Polymorphism Database (IPD)-NHKIR Database, which contains annotated KIR sequences from four non-human primate species.
Keywords
Cynomolgus, Killer-cell immunoglobulin-like receptors, Macaque species, Nomenclature, Recombinants, Rhesus, Immunology, Genetics
Citation
Bruijnesteijn, J, de Groot, N G, Otting, N, Maccari, G, Guethlein, L A, Robinson, J, Marsh, S G E, Walter, L, O’Connor, D H, Hammond, J A, Parham, P & Bontrop, R E 2019, 'Nomenclature report for killer-cell immunoglobulin-like receptors (KIR) in macaque species : new genes/alleles, renaming recombinant entities and IPD-NHKIR updates', Immunogenetics, vol. 72, no. 1-2, pp. 37-47. https://doi.org/10.1007/s00251-019-01135-8