A global effort to dissect the human genetic basis of resistance to SARS-CoV-2 infection
Publication date
2022-02
Authors
Andreakos, Evangelos
Abel, Laurent
Vinh, Donald C
Kaja, Elżbieta
Drolet, Beth A
Zhang, Qian
O'Farrelly, Cliona
Novelli, Giuseppe
Rodríguez-Gallego, Carlos
Haerynck, Filomeen
Editors
Advisors
Supervisors
Document Type
Article
Metadata
Show full item recordCollections
License
taverne
Abstract
SARS-CoV-2 infections display tremendous interindividual variability, ranging from asymptomatic infections to life-threatening disease. Inborn errors of, and autoantibodies directed against, type I interferons (IFNs) account for about 20% of critical COVID-19 cases among SARS-CoV-2-infected individuals. By contrast, the genetic and immunological determinants of resistance to infection per se remain unknown. Following the discovery that autosomal recessive deficiency in the DARC chemokine receptor confers resistance to Plasmodium vivax, autosomal recessive deficiencies of chemokine receptor 5 (CCR5) and the enzyme FUT2 were shown to underlie resistance to HIV-1 and noroviruses, respectively. Along the same lines, we propose a strategy for identifying, recruiting, and genetically analyzing individuals who are naturally resistant to SARS-CoV-2 infection.
Keywords
Animals, COVID-19/genetics, Disease Resistance/genetics, Genetic Heterogeneity, Genetic Predisposition to Disease, Host-Pathogen Interactions, Humans, Phenotype, Protective Factors, Risk Assessment, Risk Factors, SARS-CoV-2/immunology, Taverne, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review
Citation
Andreakos, E, Abel, L, Vinh, D C, Kaja, E, Drolet, B A, Zhang, Q, O'Farrelly, C, Novelli, G, Rodríguez-Gallego, C, Haerynck, F, Prando, C, Pujol, A, COVID Human Genetic Effort, Su, H C, Casanova, J-L & Spaan, A N 2022, 'A global effort to dissect the human genetic basis of resistance to SARS-CoV-2 infection', Nature immunology, vol. 23, no. 2, pp. 159-164. https://doi.org/10.1038/s41590-021-01030-z