Placental Histology After Minor Trauma in Pregnancy: A Pilot Study
Publication date
2019-05
Authors
van der Knoop, B. J.
van der Voorn, J. P.
Nikkels, Peter G J
Zonnenberg, Inge A.
van Weissenbruch, M. M.
Vermeulen, Roel
de Vries, J. I.P.
Editors
Advisors
Supervisors
Document Type
Article
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cc_by_nc
Abstract
OBJECTIVE: Trauma in pregnancy may cause placental abruption. Consequences of moderate placental injury on neurodevelopment are unknown. The aim was to evaluate placental histology after maternal trauma. METHODS: A prospective study was conducted at 2 tertiary medical centers in the Netherlands. Placentas from women exposed to maternal trauma ≥ 20 weeks' gestational age were histologically examined. Neurological follow-up of the infants was performed at 1 year of age by means of Alberta Infant Motor Scale. Histological findings were compared to placentas from pregnancies without trauma. PRINCIPAL RESULTS: Thirteen placentas were investigated in the trauma group. The control group consisted of 15 placentas. Placental pathology was seen more often in the trauma cases (11 of the 13) than in the controls (6 of the 15), P = .024. Neurological follow-up was normal. CONCLUSIONS: In this small population, majority of the placentas showed pathology after minor trauma in pregnancy without consequences for neurodevelopment at 1 year.
Keywords
brain ultrasound, neurodevelopment, placenta, placental histology, trauma in pregnancy, Prospective Studies, Humans, Gestational Age, Pregnancy, Brain/diagnostic imaging, Cesarean Section, Magnetic Resonance Imaging, Netherlands, Pilot Projects, Placenta/diagnostic imaging, Ultrasonography, Female, Infant, Newborn, Pediatrics, Perinatology, and Child Health, Pathology and Forensic Medicine, Multicenter Study, Journal Article
Citation
van der Knoop, B J, van der Voorn, J P, Nikkels, P G J, Zonnenberg, I A, van Weissenbruch, M M, Vermeulen, R J & de Vries, J I P 2019, 'Placental Histology After Minor Trauma in Pregnancy : A Pilot Study', Pediatric and Developmental Pathology, vol. 22, no. 3, pp. 221-228. https://doi.org/10.1177/1093526618799292