Human urokinase contains GalNAcβ(1-4)[Fucα(1-3)]GlcNAcα(1-2) as a novel terminal element in N-linked carbohydrate chains
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Publication date
1992
Authors
Vliegenthart, J.F.G.
Bergwerff, A.A.
Thomas-Oates, J.E.
Oostrum, J. van
Kamerling, J.P.
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Abstract
Structural analysis of enzymically released N-linked carbohydrate chains of human urokinase (urinary-type plasminogen activator) by 1H NMR spectroscopy and FAB-MS demonstrated that the N-linked oligosaccharides on the only N-glycosylation site contain diantennary structures with the novel Ga1NAc beta(1-4)[Fuc alpha(1-3)]G1cNAc beta(1-2) element in the upper or the lower branch